EGFR kinase inhibitor 4 is a bivalent ATP-allosteric inhibitor of the epidermal growth factor receptor (EGFR), demonstrating an IC50 of 1.8 nM specifically for the mutant EGFR variant (LRTMCS). This compound is primarily utilized in research focused on non-small cell lung cancer (NSCLC), providing insights into EGFR-related signaling pathways and therapeutic resistance mechanisms.
EGFR kinase inhibitor 4 is a bivalent ATP-allosteric inhibitor of the epidermal growth factor receptor (EGFR), demonstrating an IC50 of 1.8 nM specifically for the mutant EGFR variant (LRTMCS). This compound is primarily utilized in research focused on non-small cell lung cancer (NSCLC), providing insights into EGFR-related signaling pathways and therapeutic resistance mechanisms.
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