EIDD-036 is the active metabolite of EIDD-1723 and functions as a C-20 oxime derivative of Progesterone, with a notable binding affinity for the progesterone receptor (PR) demonstrated by an IC50 of 171 nM. This compound effectively penetrates the blood-brain barrier and is associated with potential therapeutic applications in acute trauma settings. EIDD-036 is specifically relevant for research in traumatic brain injury (TBI), aiding in the exploration of neuroprotective strategies following cerebral insult.
EIDD-036 is the active metabolite of EIDD-1723 and functions as a C-20 oxime derivative of Progesterone, with a notable binding affinity for the progesterone receptor (PR) demonstrated by an IC50 of 171 nM. This compound effectively penetrates the blood-brain barrier and is associated with potential therapeutic applications in acute trauma settings. EIDD-036 is specifically relevant for research in traumatic brain injury (TBI), aiding in the exploration of neuroprotective strategies following cerebral insult.
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