Elafibranor

Catalog No.: A15454

PPAR agonist

Elafibranor

Elafibranor Chemical Structure

CAS NO. 923978-27-2

Elafibranor is an agonist of the peroxisome proliferator-activated Receptor-α and -δ, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening.

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5 mg
$60.00
10 mg
$100.00
50 mg
$450.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tomasz Kostrzewski, .et al. Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system, Commun Biol, 2021, 4: 1080 PMID: 34526653
  • Joost Boeckmans, .et al. Flow cytometric quantification of neutral lipids in a human skin stem cell-derived model of NASH, MethodsX, 2020, 7: 101068 PMID: 33024711
  • Joost Boeckmans, .et al. Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists, Cell Biol Toxicol, 2020, Jul 1 PMID: 32613381
  • Joost Boeckmans, .et al. Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor, Data in Brief, 2019, June 3 PMID: 31294056
  • Boeckmans J, .et al. Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH, Pharmacol Res, 2019, Apr 24. pii: S1043-6618(18)31850-4 PMID: 31028903

Biological Activity

Elafibranor is an agonist of the peroxisome proliferator-activated Receptor-α and -δ, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening.
In vitro DMSO 74 mg/mL (192.46 mM)
Water Insoluble
Ethanol 74 mg/mL (192.46 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.01 mL 130.04 mL 260.08 mL
0.5 mM 5.2 mL 26.01 mL 52.02 mL
1 mM 2.6 mL 13 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL

*The above data is based on the productmolecular weight 384.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15454
Actions Agonist
CAS No. 923978-27-2
Formula C22H24O4S
M. Wt 384.49
Purity >98%
Synonyms GFT505, GFT-505, GFT 505
SMILES CC1=CC(=CC(=C1OC(C)(C)C(=O)O)C)C=CC(=O)C2=CC=C(C=C2)SC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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