EM12-SO2F is a potent covalent inhibitor of the E3 ubiquitin ligase cereblon (CRBN), specifically binding to the histidine residue at position 353. This compound serves as a valuable chemical probe for studying CRBN-mediated pathways. EM12-SO2F effectively inhibits the lenalidomide-induced degradation of IKZF1 in MOLT4 cells, making it a useful tool for research in cancer biology and drug resistance.
EM12-SO2F is a potent covalent inhibitor of the E3 ubiquitin ligase cereblon (CRBN), specifically binding to the histidine residue at position 353. This compound serves as a valuable chemical probe for studying CRBN-mediated pathways. EM12-SO2F effectively inhibits the lenalidomide-induced degradation of IKZF1 in MOLT4 cells, making it a useful tool for research in cancer biology and drug resistance.
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