Epertinib hydrochloride

Catalog No.: A21950

EGFR, HER2 and HER4 inhibitor

Epertinib hydrochloride

Epertinib hydrochloride Chemical Structure

CAS NO. 2071195-74-7

Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity.

Availability: In stock

Package Price Qty
5 mg
$315.00
10 mg
$543.00
50 mg
$1,610.00
100 mg
$3,220.00
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Biological Activity

Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity.
In vitro DMSO 88 mg/mL (147.53 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.77 mL 83.83 mL 167.65 mL
0.5 mM 3.35 mL 16.77 mL 33.53 mL
1 mM 1.68 mL 8.38 mL 16.77 mL
5 mM 0.34 mL 1.68 mL 3.35 mL

*The above data is based on the productmolecular weight 596.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21950
Actions Inhibitor
CAS No. 2071195-74-7
Formula C30H28Cl2FN5O3
M. Wt 596.48
Solubility DMSO
Purity >98%
Synonyms S-22611 hydrochloride, S22611, S 22611
SMILES CC#C/C(C1=CC2=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)N=CN=C2C=C1)=N\OC[[email protected]@H]5NCCOC5.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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