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EPZ-5676 (Pinometostat)

Catalog No.: A12735

DOT1L Inhibitor‎

EPZ-5676 (Pinometostat)

EPZ-5676 (Pinometostat) Chemical Structure

CAS NO. 1380288-87-8

EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity.

Availability: In stock

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5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yoo H, .et al. Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function, Cell Death Dis, 2020, Jan; 11(1): 14 PMID: 31908356
  • Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48

Biological Activity

EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity.
DOT1L (Cell-free assay)
80 pM(Ki)
In vitro (25°C) DMSO Warmed: 88 mg/mL (156.38 mM)
Water Insoluble
Ethanol Warmed: 81 mg/mL (143.94 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.77 mL 88.86 mL 177.71 mL
0.5 mM 3.55 mL 17.77 mL 35.54 mL
1 mM 1.78 mL 8.89 mL 17.77 mL
5 mM 0.36 mL 1.78 mL 3.55 mL

*The above data is based on the productmolecular weight 562.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12735
Actions Inhibitor
CAS No. 1380288-87-8
Formula C30H42N8O3
M. Wt 562.7
Purity >98%
Synonyms EPZ5676, EPZ 5676
SMILES CC(C)N(C[[email protected]@H]1[[email protected]]([[email protected]]([[email protected]@H](O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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