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- Yoo H, .et al. Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function, Cell Death Dis, 2020, Jan; 11(1): 14 PMID: 31908356
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
Biological Activity
EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity.
Targets
| DOT1L (Cell-free assay) | ||||
| 80 pM(Ki) |
| In vitro (25°C) | DMSO | Warmed: 88 mg/mL (156.38 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 81 mg/mL (143.94 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.77 mL | 88.86 mL | 177.71 mL |
| 0.5 mM | 3.55 mL | 17.77 mL | 35.54 mL |
| 1 mM | 1.78 mL | 8.89 mL | 17.77 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.55 mL |
*The above data is based on the productmolecular weight 562.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12735 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1380288-87-8 |
| Formula | C30H42N8O3 |
| M. Wt | 562.7 |
| Purity | >98% |
| Synonyms | EPZ5676, EPZ 5676 |
| SMILES | CC(C)N(C[[email protected]@H]1[[email protected]]([[email protected]]([[email protected]@H](O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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