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Publications citing Adooq Products
Chemical Information
| Catalog Num | A12983 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 539.67 |
| Formula | C28H41N7O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1338466-77-5 |
| Synonyms | EPZ 004777, EPZ-004777 |
| SMILES code | CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[[email protected]@H]2[[email protected]]([[email protected]]([[email protected]@H](O2)N3C=CC4=C3N=CN=C4N)O)O |
| Chemical Name | 1-(3-((((2R,3S,4R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea |
Description |
EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. | ||||||||||
Targets |
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| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (185.29 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 100 mg/mL (185.29 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.53 mL | 92.65 mL | 185.3mL |
| 0.5 mM | 3.71 mL | 18.53 mL | 37.06 mL |
| 1 mM | 1.85 mL | 9.26 mL | 18.53 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.71 mL |
*The above data is based on the productmolecular weight 539.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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