EPZ004777

Catalog No.: A12983

DOT1L inhibitor

EPZ004777

EPZ004777 Chemical Structure

CAS NO. 1338466-77-5

EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.

Availability: In stock

Package Price Qty
5 mg
$110.00
10 mg
$190.00
25 mg
$290.00
50 mg
$550.00
10mM * 1mL in DMSO
$131.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.
Targets
DOT1L (Cell-free assay)
0.4 nM
In vitro DMSO 100 mg/mL (185.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (185.29 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.53 mL 92.65 mL 185.3 mL
0.5 mM 3.71 mL 18.53 mL 37.06 mL
1 mM 1.85 mL 9.26 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL

*The above data is based on the productmolecular weight 539.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12983
Actions Inhibitor
M. Wt 539.67
Formula C28H41N7O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1338466-77-5
Synonyms EPZ 004777, EPZ-004777
SMILES CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[[email protected]@H]2[[email protected]]([[email protected]]([[email protected]@H](O2)N3C=CC4=C3N=CN=C4N)O)O

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy EPZ004777 | EPZ004777 Supplier | purchase EPZ004777 | EPZ004777 cost | EPZ004777 manufacturer | order EPZ004777 | EPZ004777 distributor | buy 1338466-77-5| 1338466-77-5 Supplier | purchase 1338466-77-5 | 1338466-77-5 cost | 1338466-77-5 manufacturer | order 1338466-77-5 | 1338466-77-5 distributor
Rewards