EPZ011989

Catalog No.: A15544

EZH2 Inhibitor

EPZ011989 Chemical Structure

CAS NO. 1598383-40-4

EPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.

Availability: In stock

Package Price Qty
5 mg
$55.00
10 mg
$85.00
25 mg
$140.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

EPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.51 mL 82.53 mL 165.07 mL
0.5 mM 3.3 mL 16.51 mL 33.01 mL
1 mM 1.65 mL 8.25 mL 16.51 mL
5 mM 0.33 mL 1.65 mL 3.3 mL

*The above data is based on the productmolecular weight 605.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15544
Actions Inhibitor
M. Wt 605.81
Formula C35H51N5O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1598383-40-4
Synonyms EPZ-011989, EPZ 011989
SMILES CCN(C1CCC(CC1)N(C)CCOC)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C#CCN4CCOCC4

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