Erlotinib-d8 is a deuterium-labeled variant of Erlotinib, a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, exhibiting an IC50 of 2 nM for human EGFR. This compound effectively reduces EGFR autophosphorylation in intact tumor cells, demonstrating an IC50 of 20 nM. Erlotinib-d8 is suited for applications in stable isotope labeling studies and can function as a click chemistry reagent, containing an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
Erlotinib-d8 is a deuterium-labeled variant of Erlotinib, a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, exhibiting an IC50 of 2 nM for human EGFR. This compound effectively reduces EGFR autophosphorylation in intact tumor cells, demonstrating an IC50 of 20 nM. Erlotinib-d8 is suited for applications in stable isotope labeling studies and can function as a click chemistry reagent, containing an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
