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Biological Activity
Esaxerenone, also known as CS-3150, XL-550, is a nonsteroidal antimineralocorticoid that acts as a highly selective silent antagonist of the mineralocorticoid receptor (MR), the receptor for aldosterone, with greater than 1,000-fold selectivity for this receptor over other steroid hormone receptors, and 4-fold and 76-fold higher affinity for the MR relative to the existing antimineralocorticoids spironolactone and eplerenone.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.44 mL | 107.19 mL | 214.38 mL |
| 0.5 mM | 4.29 mL | 21.44 mL | 42.88 mL |
| 1 mM | 2.14 mL | 10.72 mL | 21.44 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.29 mL |
*The above data is based on the productmolecular weight 466.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16925 |
|---|---|
| Actions | Antagonist |
| CAS No. | 1632006-28-0 |
| Formula | C22H21F3N2O4S |
| M. Wt | 466.47 |
| Purity | >98% |
| Synonyms | CS-3150, CS 3150, CS3150, XL-550, XL550, L 550 |
| SMILES | CS(C1=CC=C(NC(C2=CN(CCO)C(C3=CC=CC=C3C(F)(F)F)=C2C)=O)C=C1)(=O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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