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Escin IA

Catalog No.: A12053
LOXL2 Inhibitor, EMT Inhibitor
Escin IA is a selective LOXL2 inhibitor that targets epithelial-mesenchymal transition (EMT), effectively suppressing cell invasion, migration, and metastasis in breast cancer models. Derived from the Aesculus chinensis Bunge fruit saponin fraction, it is identified as a key component in mitigating triple-negative breast cancer metastasis. Additionally, Escin IA has potential applications in studying acute inflammation and ethanol-induced gastric mucosal lesions.
Escin IA 123748-68-5 LOXL2 Inhibitor, EMT Inhibitor
Grouped product items
Size Price Stock Qty
5mg
$140.00
In stock
10mg
$240.00
In stock
25mg
$410.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionEscin IA is a selective LOXL2 inhibitor that targets epithelial-mesenchymal transition (EMT), effectively suppressing cell invasion, migration, and metastasis in breast cancer models. Derived from the Aesculus chinensis Bunge fruit saponin fraction, it is identified as a key component in mitigating triple-negative breast cancer metastasis. Additionally, Escin IA has potential applications in studying acute inflammation and ethanol-induced gastric mucosal lesions.
Product Information
Catalog NumA12053
FormulaC55H86O24
Molecular Weight1131.26
CAS Number123748-68-5
SMILESOC[C@]1([C@H]2OC(C)=O)[C@](CC(C)(C)[C@H]2OC(/C(C)=C/C)=O)([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(CC[C@H](O[C@@](O[C@H](C(O)=O)[C@@H](O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)[C@@H]7O)([H])[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]8O)O)([H])O[C@@H]8CO)[C@]5(C)CO)C)[C@]3(C)C[C@H]1O
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