Evacetrapib (LY2484595)

Catalog No.: A11397

CETP inhibitor

Evacetrapib (LY2484595)

Evacetrapib (LY2484595) Chemical Structure

CAS NO. 1186486-62-3

Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3.

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$240.00
25 mg
$500.00
50 mg
$750.00
10mM * 1mL in DMSO
$211.00
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Biological Activity

Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3.
Targets
CETP
5.5 nM
In vitro (25°C) DMSO 11 mg/mL (17.22 mM)
Water Insoluble
Ethanol 11 mg/mL (17.22 mM)
In vivo 15% Captisol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.66 mL 78.29 mL 156.58 mL
0.5 mM 3.13 mL 15.66 mL 31.32 mL
1 mM 1.57 mL 7.83 mL 15.66 mL
5 mM 0.31 mL 1.57 mL 3.13 mL

*The above data is based on the productmolecular weight 638.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11397
Actions Inhibitor
CAS No. 1186486-62-3
Formula C31H36F6N6O2
M. Wt 638.65
Purity >98%
Synonyms LY2484595, LY-2484595, LY 2484595
SMILES CC1=CC(=C2C(=C1)[[email protected]](CCCN2CC3CCC(CC3)C(=O)O)N(CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=NN(N=N5)C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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