F44-A13 is a highly selective antagonist of the farnesoid X receptor (FXR), exhibiting an IC50 value of 1.1 μM. This compound modulates cholesterol metabolism by inducing the expression of CYP7A1, leading to significant reductions in cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) in murine models. F44-A13 serves as a valuable tool for investigating metabolic diseases related to lipid dysregulation.
F44-A13 is a highly selective antagonist of the farnesoid X receptor (FXR), exhibiting an IC50 value of 1.1 μM. This compound modulates cholesterol metabolism by inducing the expression of CYP7A1, leading to significant reductions in cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) in murine models. F44-A13 serves as a valuable tool for investigating metabolic diseases related to lipid dysregulation.
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