FG-4592 (Roxadustat)

Name: FG-4592 (Roxadustat)
Brand: Adooq Bioscience
SKU: A11237
Rating: 100 (4 reviews)

Catalog No.: A11237

HIF-PHs inhibitor

Product Citations (4)

FG-4592 (Roxadustat) Chemical Structure

CAS NO. 808118-40-3

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.

Availability: In stock

Package	Price	Qty
10 mg	$50.00
50 mg	$100.00
100 mg	$130.00	Out of stock
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq FG-4592 (Roxadustat)

Singh C, .et al. Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity, JCI Insight, 2019, Jul 25;4(14) PMID: 31341109
Hideaki Nakamura, .et al. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLoS One, 2018, 13(2): e0192136 PMID: 29466367
Singh C, .et al. 3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis, Invest Ophthalmol Vis Sci, 2018, Jul 2;59(8):3440-3448 PMID: 30025089
George Hoppe, .et al. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity, Proc Natl Acad Sci U S A, 2016, May 3; 113(18): E2516–E2525 PMID: 27091985

Biological Activity

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.

Targets

HIF α prolyl hydroxylase (Cell-free assay)

Solubility *

In vitro (25°C)	DMSO	62 mg/mL (175.96 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.38 mL	141.92 mL	283.85 mL
0.5 mM	5.68 mL	28.38 mL	56.77 mL
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL

*The above data is based on the productmolecular weight 352.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11237
Actions	Inhibitor
CAS No.	808118-40-3
Formula	C19H16N2O5
M. Wt	352.3
Purity	>98%
Synonyms	FG4592, ASP1517
SMILES	CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.