FG-4592 (Roxadustat)

Name: FG-4592 (Roxadustat)
SKU: A11237
Price: 25 USD
Rating: 5 (5 reviews)

Catalog No.: A11237

HIF-PHs inhibitor

Adooq's FG-4592 (Roxadustat) has been cited by 5 publications

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.

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Grouped product items
Size	Price	Stock
5mg	$25.00	In stock
10mg	$40.00	In stock
25mg	$60.00	In stock
50mg	$80.00	In stock
100mg	$110.00	In stock
200mg	$200.00	In stock
500mg	$280.00	In stock
1g	$540.00	In stock
*10mM 1mL in DMSO**	$40.00	In stock
Bulk Size	Bulk Discount

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Important Notice: For research use only. We do not sell to patients.

Data Sheet

SDS

Adooq Products cited in reputable paper

Adooq's FG-4592 (Roxadustat) has been cited by 5 publications

Weilin Song, .et al. , Biomedicines, 2022, Dec 23;11(1):37 PMID: 36672545

Singh C, .et al. , JCI Insight, 2019, Jul 25;4(14) PMID: 31341109

Hideaki Nakamura, .et al. , PLoS One, 2018, 13(2): e0192136 PMID: 29466367

Singh C, .et al. , Invest Ophthalmol Vis Sci, 2018, Jul 2;59(8):3440-3448 PMID: 30025089

George Hoppe, .et al. , Proc Natl Acad Sci U S A, 2016, May 3; 113(18): E2516-E2525 PMID: 27091985

Biological Activity

Discription

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.

Targets

Target	Value

Product Information

Catalog Num	A11237
Formula	C19H16N2O5
Molecular Weight	352.3
CAS Number	808118-40-3
SMILES	CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O
Synonyms	FG4592, ASP1517
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	62 mg/mL (175.96 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.38 mL	141.92 mL	283.85 mL
0.5 mM	5.68 mL	28.38 mL	56.77 mL
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL

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