FG-4592 (Roxadustat)

Catalog No.: A11237

HIF-PHs inhibitor

FG-4592 (Roxadustat) Chemical Structure

CAS NO. 808118-40-3

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.

Availability: In stock

Package Price Qty
10 mg
$50.00
50 mg
$100.00
100 mg
$130.00
10mM * 1mL in DMSO
$50.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.
Targets
HIF α prolyl hydroxylase (Cell-free assay)
In vitro DMSO 70 mg/mL (198.67 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.38 mL 141.92 mL 283.85 mL
0.5 mM 5.68 mL 28.38 mL 56.77 mL
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL

*The above data is based on the productmolecular weight 352.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11237
Actions Inhibitor
M. Wt 352.3
Formula C19H16N2O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 808118-40-3
Synonyms FG4592, ASP1517
SMILES CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O

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