FG 7142 is a non-selective inverse agonist of the GABAA receptor, exhibiting high affinity for the α1 subunit (Ki = 91 nM). It effectively modulates GABA-induced chloride flux at GABAA receptors containing the α1 subunit (EC50 = 137 nM). Additionally, FG 7142 has been shown to enhance tyrosine hydroxylation and upregulate β-adrenoceptors in the mouse cerebral cortex, making it valuable for research in neuropharmacology and the study of anxiety-related disorders.
FG 7142 is a non-selective inverse agonist of the GABAA receptor, exhibiting high affinity for the α1 subunit (Ki = 91 nM). It effectively modulates GABA-induced chloride flux at GABAA receptors containing the α1 subunit (EC50 = 137 nM). Additionally, FG 7142 has been shown to enhance tyrosine hydroxylation and upregulate β-adrenoceptors in the mouse cerebral cortex, making it valuable for research in neuropharmacology and the study of anxiety-related disorders.
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