Fidaxomicin

Catalog No.: A13271

Fidaxomicin

Fidaxomicin Chemical Structure

CAS NO. 873857-62-6

Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.

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Package Price Qty
1 mg

Regular Price: $20.00

Special Price $16.00

2 mg

Regular Price: $30.00

Special Price $24.00

5 mg

Regular Price: $50.00

Special Price $40.00

10 mg

Regular Price: $65.00

Special Price $52.00

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Biological Activity

Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.
Targets
RNA polymerase
In vitro DMSO 92 mg/mL (86.95 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 9.45 mL 47.26 mL 94.51 mL
0.5 mM 1.89 mL 9.45 mL 18.9 mL
1 mM 0.95 mL 4.73 mL 9.45 mL
5 mM 0.19 mL 0.95 mL 1.89 mL

*The above data is based on the productmolecular weight 1058.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13271
CAS No. 873857-62-6
Formula C52H74Cl2O18
M. Wt 1058.04
Purity >98%
SMILES CC[[email protected]]1/C=C(\[[email protected]](C/C=C/C=C(/C(=O)O[[email protected]@H](C/C=C(/C=C(/C1O[[email protected]]2[[email protected]]([[email protected]]([[email protected]@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\C)\C)[[email protected]@H](C)O)\CO[[email protected]]3[[email protected]]([[email protected]]([[email protected]@H]([[email protected]](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)/C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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