Finerenone is a selective nonsteroidal mineralocorticoid receptor (MR) antagonist with a reported IC50 of 18 nM. It demonstrates high selectivity against glucocorticoid, androgen, and progesterone receptors, with over 500-fold preference. Finerenone is relevant for researching therapeutic interventions in cardiorenal diseases, particularly in the context of type 2 diabetes mellitus and chronic kidney disease.
Finerenone is a selective nonsteroidal mineralocorticoid receptor (MR) antagonist with a reported IC50 of 18 nM. It demonstrates high selectivity against glucocorticoid, androgen, and progesterone receptors, with over 500-fold preference. Finerenone is relevant for researching therapeutic interventions in cardiorenal diseases, particularly in the context of type 2 diabetes mellitus and chronic kidney disease.
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