Firibastat is a potent inhibitor of aminopeptidase A (APA), exhibiting a Ki value of 200 nM. This first-in-class compound effectively inhibits the conversion of brain angiotensin-II to angiotensin-III, resulting in reduced blood pressure in hypertensive models. Firibastat is particularly valuable in exploring the role of APA in neurophysiological processes and hypertension research.
Firibastat is a potent inhibitor of aminopeptidase A (APA), exhibiting a Ki value of 200 nM. This first-in-class compound effectively inhibits the conversion of brain angiotensin-II to angiotensin-III, resulting in reduced blood pressure in hypertensive models. Firibastat is particularly valuable in exploring the role of APA in neurophysiological processes and hypertension research.
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