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- Takeshi Nakamura, .et al. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells, Shimane Journal of Medical Science, 2022, 38 (2), 59-66
- Takeshi Katayoshi, .et al. Restoring NAD + by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes, J Photochem Photobiol B, 2021, Jun 12;221:112238 PMID: 34130091
- Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7
- Peter M LoCoco, .et al. Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy, eLife, 2017, 6: e29626 PMID: 29125463
Biological Activity
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.
Targets
NMPRTase (Cell-free assay) | ||||
0.09 nM |
In vitro (25°C) | DMSO | Insoluble | |
Water | Insoluble | ||
Ethanol | 77 mg/mL (196.67 mM) | ||
In vivo | 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O | 3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.54 mL | 127.71 mL | 255.43 mL |
0.5 mM | 5.11 mL | 25.54 mL | 51.09 mL |
1 mM | 2.55 mL | 12.77 mL | 25.54 mL |
5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
*The above data is based on the productmolecular weight 391.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11279 |
---|---|
Actions | Inhibitor |
CAS No. | 658084-64-1 |
Formula | C24H29N3O2 |
M. Wt | 391.5 |
Purity | >98% |
Synonyms | K 22.175, FK-866 |
SMILES | C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC=CC=C3 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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