FK866

Catalog No.: A11279

NMPRTase Inhibitor

FK866

FK866 Chemical Structure

CAS NO. 658084-64-1

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.

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10 mg

Regular Price: $100.00

Special Price $80.00

25 mg

Regular Price: $240.00

Special Price $192.00

50 mg

Regular Price: $380.00

Special Price $304.00

100 mg

Regular Price: $640.00

Special Price $512.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Peter M LoCoco, .et al. Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy, eLife, 2017, 6: e29626 PMID: 29125463

Biological Activity

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.
Targets
NMPRTase (Cell-free assay)
0.09 nM
In vitro (25°C) DMSO Insoluble
Water Insoluble
Ethanol 77 mg/mL (196.67 mM)
In vivo 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.54 mL 127.71 mL 255.43 mL
0.5 mM 5.11 mL 25.54 mL 51.09 mL
1 mM 2.55 mL 12.77 mL 25.54 mL
5 mM 0.51 mL 2.55 mL 5.11 mL

*The above data is based on the productmolecular weight 391.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11279
Actions Inhibitor
CAS No. 658084-64-1
Formula C24H29N3O2
M. Wt 391.5
Purity >98%
Synonyms K 22.175, FK-866
SMILES C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC=CC=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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