FK866

Name: FK866
Brand: Adooq Bioscience
SKU: A11279
Rating: 100 (4 reviews)

Catalog No.: A11279

NMPRTase Inhibitor

Product Citations (4)

FK866 Chemical Structure

CAS NO. 658084-64-1

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.

Availability: In stock

Package	Price	Qty
10 mg	$100.00
25 mg	$240.00
50 mg	$380.00
100 mg	$640.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq FK866

Takeshi Nakamura, .et al. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells, Shimane Journal of Medical Science, 2022, 38 (2), 59-66
Takeshi Katayoshi, .et al. Restoring NAD + by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes, J Photochem Photobiol B, 2021, Jun 12;221:112238 PMID: 34130091
Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7
Peter M LoCoco, .et al. Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy, eLife, 2017, 6: e29626 PMID: 29125463

Biological Activity

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.

Targets

NMPRTase (Cell-free assay)
0.09 nM

Solubility *

In vitro (25°C)	DMSO	Insoluble
	Water	Insoluble
	Ethanol	77 mg/mL (196.67 mM)
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.54 mL	127.71 mL	255.43 mL
0.5 mM	5.11 mL	25.54 mL	51.09 mL
1 mM	2.55 mL	12.77 mL	25.54 mL
5 mM	0.51 mL	2.55 mL	5.11 mL

*The above data is based on the productmolecular weight 391.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11279
Actions	Inhibitor
CAS No.	658084-64-1
Formula	C24H29N3O2
M. Wt	391.5
Purity	>98%
Synonyms	K 22.175, FK-866
SMILES	C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC=CC=C3
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.