Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs), incorporating a hydrophilic PEG spacer and a Val-Cit-PAB dipeptide. The structure includes a benzylic alcohol on the PAB, facilitating conjugation with reactive drug payloads. Upon Fmoc group removal with piperidine, a primary amine is exposed, enabling further coupling reactions to create amide bonds. The Val-Cit-PAB motif is selectively cleaved by cellular proteases, allowing for the effective release of therapeutic agents within target cells.
Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs), incorporating a hydrophilic PEG spacer and a Val-Cit-PAB dipeptide. The structure includes a benzylic alcohol on the PAB, facilitating conjugation with reactive drug payloads. Upon Fmoc group removal with piperidine, a primary amine is exposed, enabling further coupling reactions to create amide bonds. The Val-Cit-PAB motif is selectively cleaved by cellular proteases, allowing for the effective release of therapeutic agents within target cells.
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