Fmoc-PEG6-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs) that comprises a hydrophilic PEG spacer, a Boc-protected amine, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB allows for conjugation with reactive groups, such as PNP, to facilitate the attachment of drug payloads. The Fmoc protecting group can be removed using piperidine, exposing a primary amine for subsequent amide bond formation. The Val-Cit-PAB moiety is efficiently cleaved by cellular proteases, ensuring targeted release of therapeutic agents within the cells.
Fmoc-PEG6-Val-Cit-PAB-OH is an enzyme-cleavable linker designed for antibody-drug conjugates (ADCs) that comprises a hydrophilic PEG spacer, a Boc-protected amine, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB allows for conjugation with reactive groups, such as PNP, to facilitate the attachment of drug payloads. The Fmoc protecting group can be removed using piperidine, exposing a primary amine for subsequent amide bond formation. The Val-Cit-PAB moiety is efficiently cleaved by cellular proteases, ensuring targeted release of therapeutic agents within the cells.
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