Freselestat (ONO-6818)

Catalog No.: A12780

Neutrophil elastase inhibitor

Freselestat (ONO-6818)

Freselestat (ONO-6818) Chemical Structure

CAS NO. 208848-19-5

Freselestat is a potent neutrophil elastase inhibitor. Freselestat reduces inflammatory mediators during simulated extracorporeal circulation. ONO-6818 significantly reduced interleukin 8 and C5b-9 production. ONO-6818 did not modulate changes of CD11b and L-selectin during recirculation.

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5 mg

Regular Price: $450.00

Special Price $360.00

10 mg

Regular Price: $850.00

Special Price $680.00

25 mg

Regular Price: $1,600.00

Special Price $1,280.00

50 mg

Regular Price: $3,000.00

Special Price $2,400.00

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Biological Activity

Freselestat is a potent neutrophil elastase inhibitor. Freselestat reduces inflammatory mediators during simulated extracorporeal circulation. ONO-6818 significantly reduced interleukin 8 and C5b-9 production. ONO-6818 did not modulate changes of CD11b and L-selectin during recirculation.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.1 mL 110.49 mL 220.99 mL
0.5 mM 4.42 mL 22.1 mL 44.2 mL
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL

*The above data is based on the productmolecular weight 452.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12780
Actions Inhibitor
CAS No. 208848-19-5
Formula C23H28N6O4
M. Wt 452.51
Purity >98%
Synonyms ONO6818, ONO 6818
SMILES C3=C(C1=NC=C(C(N1CC(NC(C(C2=NN=C(O2)C(C)(C)C)=O)C(C)C)=O)=O)N)C=CC=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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