Fig. 1 · Structure
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Fruquintinib-d6
Stable Isotope
Fruquintinib-d6 is the deuterated form of Fruquintinib, a highly selective and potent inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 (VEGFR 1/2/3). This compound demonstrates inhibitory activity with IC50 values of 33 nM for VEGFR-1, 0.35 nM for VEGFR-2, and 35 nM for VEGFR-3. Fruquintinib-d6 is primarily utilized in pharmacokinetic studies and metabolic profiling, providing valuable insights for cancer research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2978508-76-6 |
| Applications | Stable Isotope |
| Formula | C21H13D6N3O5 |
| Molecular Weight | 399.43 |
| SMILES | CNC(C1=C(C)OC2=CC(OC3=NC=NC4=C3C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C4)=CC=C12)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.