Fruquintinib-d6 is the deuterated form of Fruquintinib, a highly selective and potent inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 (VEGFR 1/2/3). This compound demonstrates inhibitory activity with IC50 values of 33 nM for VEGFR-1, 0.35 nM for VEGFR-2, and 35 nM for VEGFR-3. Fruquintinib-d6 is primarily utilized in pharmacokinetic studies and metabolic profiling, providing valuable insights for cancer research and therapeutic development.
Fruquintinib-d6 is the deuterated form of Fruquintinib, a highly selective and potent inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 (VEGFR 1/2/3). This compound demonstrates inhibitory activity with IC50 values of 33 nM for VEGFR-1, 0.35 nM for VEGFR-2, and 35 nM for VEGFR-3. Fruquintinib-d6 is primarily utilized in pharmacokinetic studies and metabolic profiling, providing valuable insights for cancer research and therapeutic development.
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