FXR Agonist 12 is a selective agonist for the farnesoid X receptor (FXR). It effectively down-regulates genes associated with bile acid synthesis while up-regulating those involved in bile acid transport in HepG2 cells. In preclinical studies, FXR Agonist 12 has demonstrated the capability to improve cholestasis induced by ANIT and to mitigate liver damage and fibrosis in mouse models of non-alcoholic steatohepatitis (NASH). This compound is instrumental for research focusing on liver disorders and bile acid metabolism.
FXR Agonist 12 is a selective agonist for the farnesoid X receptor (FXR). It effectively down-regulates genes associated with bile acid synthesis while up-regulating those involved in bile acid transport in HepG2 cells. In preclinical studies, FXR Agonist 12 has demonstrated the capability to improve cholestasis induced by ANIT and to mitigate liver damage and fibrosis in mouse models of non-alcoholic steatohepatitis (NASH). This compound is instrumental for research focusing on liver disorders and bile acid metabolism.
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