FXR agonist 14 is a selective, orally bioavailable agonist of the farnesoid X receptor (FXR), exhibiting an EC50 of 0.67 nM. This compound demonstrates significant biological activity by alleviating pathological features associated with metabolic syndrome in high-fat and high-sugar diet-induced MASH mice. Additionally, FXR agonist 14 plays a crucial role in exerting protective effects against anti-cholestatic liver disease, making it valuable for research in liver and metabolic disorders.
FXR agonist 14 is a selective, orally bioavailable agonist of the farnesoid X receptor (FXR), exhibiting an EC50 of 0.67 nM. This compound demonstrates significant biological activity by alleviating pathological features associated with metabolic syndrome in high-fat and high-sugar diet-induced MASH mice. Additionally, FXR agonist 14 plays a crucial role in exerting protective effects against anti-cholestatic liver disease, making it valuable for research in liver and metabolic disorders.
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