FXR Agonist 15 is a potent and selective farnesoid X receptor (FXR) agonist with an EC50 of 0.76 μM. This compound shows high specificity, exhibiting minimal activation of other nuclear receptors such as LXRα/β, PXR, PPARα/β/γ, and THR-β, with EC50 values greater than 10 μM. FXR Agonist 15 demonstrates the ability to mitigate steatosis, lobular inflammation, hepatocyte ballooning, and liver fibrosis, making it a valuable tool for research into nonalcoholic steatohepatitis (NASH).
FXR Agonist 15 is a potent and selective farnesoid X receptor (FXR) agonist with an EC50 of 0.76 μM. This compound shows high specificity, exhibiting minimal activation of other nuclear receptors such as LXRα/β, PXR, PPARα/β/γ, and THR-β, with EC50 values greater than 10 μM. FXR Agonist 15 demonstrates the ability to mitigate steatosis, lobular inflammation, hepatocyte ballooning, and liver fibrosis, making it a valuable tool for research into nonalcoholic steatohepatitis (NASH).
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