FY-21 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 340 nM. This compound demonstrates significant anti-proliferative effects and inhibits colony formation in cancer cells. Additionally, FY-21 enhances p53 expression while down-regulating HOXA9 and MEIS1, contributing to its potential in inducing differentiation in leukemia cells, thereby providing a promising avenue for antitumor research applications.
FY-21 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 340 nM. This compound demonstrates significant anti-proliferative effects and inhibits colony formation in cancer cells. Additionally, FY-21 enhances p53 expression while down-regulating HOXA9 and MEIS1, contributing to its potential in inducing differentiation in leukemia cells, thereby providing a promising avenue for antitumor research applications.
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