GABA-A Receptor Ligand-1

Catalog No.: A66855
GABA Receptor Ligand
GABA-A Receptor Ligand-1 is a selective ligand for the GABA-A receptor, exhibiting a pKi of 7.27. This compound demonstrates significant neuroprotective effects, reducing mitochondrial dysfunction and promoting both neurite outgrowth and neuronal regeneration. Research applications include studies on ischemic stroke models in rats, highlighting its potential for therapeutic interventions in neurodegenerative conditions.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGABA-A Receptor Ligand-1 is a selective ligand for the GABA-A receptor, exhibiting a pKi of 7.27. This compound demonstrates significant neuroprotective effects, reducing mitochondrial dysfunction and promoting both neurite outgrowth and neuronal regeneration. Research applications include studies on ischemic stroke models in rats, highlighting its potential for therapeutic interventions in neurodegenerative conditions.
Product Information
Catalog NumA66855
FormulaC20H20FN3O
Molecular Weight337.39
CAS Number3076335-23-1
SMILESCC(C=C1)=CN2C1=NC(C3=CC=C(C=C3)F)=C2CC(N4CCCC4)=O
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