GABA receptor antagonist 2

Catalog No.: A66901
GABA Receptor Antagonist
GABA receptor antagonist 2 targets the GABA receptor and exhibits insecticidal properties against Plutella xylostella, including its resistant strains, as well as Spodoptera frugiperda and Chilo suppressalis. With a lethal concentration (LC50) of 0.0735 μg/mL, this compound effectively disrupts GABAergic signaling by binding at the Drosophila RdlG335 site. GABA receptor antagonist 2 serves as a valuable tool in managing resistant pest populations in agricultural research applications.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGABA receptor antagonist 2 targets the GABA receptor and exhibits insecticidal properties against Plutella xylostella, including its resistant strains, as well as Spodoptera frugiperda and Chilo suppressalis. With a lethal concentration (LC50) of 0.0735 μg/mL, this compound effectively disrupts GABAergic signaling by binding at the Drosophila RdlG335 site. GABA receptor antagonist 2 serves as a valuable tool in managing resistant pest populations in agricultural research applications.
Product Information
Catalog NumA66901
FormulaC27H17BrF12N2O3
Molecular Weight725.32
CAS Number2922115-20-4
SMILESFC(C(F)(F)F)(C(F)(F)F)C1=CC(Br)=C(C(C(F)(F)F)=C1)NC(C2=C(C(N(C(C3=CC=C(C=C3)F)=O)CCOC)=CC=C2)F)=O
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