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GABAA receptor modulator-12

Catalog No.: A66792
GABAA Receptor Modulator
GABAA receptor modulator-12 is a potent modulator of the GABAA receptor, specifically inhibiting anesthetic-induced desensitization of the GABAA α3β3γ2 subtype with an IC50 of 0.2 μM. This compound is effective in research applications related to central nervous system disorders, contributing valuable insights into neuropharmacology and therapeutic interventions.
GABAA receptor modulator-12 6252-98-8 GABAA Receptor Modulator
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGABAA receptor modulator-12 is a potent modulator of the GABAA receptor, specifically inhibiting anesthetic-induced desensitization of the GABAA α3β3γ2 subtype with an IC50 of 0.2 μM. This compound is effective in research applications related to central nervous system disorders, contributing valuable insights into neuropharmacology and therapeutic interventions.
Product Information
Catalog NumA66792
FormulaC11H10N2O2
Molecular Weight202.21
CAS Number6252-98-8
SMILESO=C(C1(C(C=CC=C2)=C2CC1)N3)NC3=O
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Neuronal Signaling > GABA Receptors