Gartisertib-d8 is a deuterated analog of Gartisertib, serving as a stable isotope labeled compound. As an ATP-competitive and selective inhibitor of ATR, Gartisertib exhibits a high binding affinity with a Ki of less than 150 pM. It effectively inhibits ATR-mediated phosphorylation of checkpoint kinase 1 (Chk1) with an IC50 of 8 nM, demonstrating significant antitumor activity. This reagent is suitable for research applications in cancer biology, particularly in studies focusing on DNA damage response and checkpoint regulation.
Gartisertib-d8 is a deuterated analog of Gartisertib, serving as a stable isotope labeled compound. As an ATP-competitive and selective inhibitor of ATR, Gartisertib exhibits a high binding affinity with a Ki of less than 150 pM. It effectively inhibits ATR-mediated phosphorylation of checkpoint kinase 1 (Chk1) with an IC50 of 8 nM, demonstrating significant antitumor activity. This reagent is suitable for research applications in cancer biology, particularly in studies focusing on DNA damage response and checkpoint regulation.
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