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Gartisertib-d8

Stable Isotope

Gartisertib-d8 is a deuterated analog of Gartisertib, serving as a stable isotope labeled compound. As an ATP-competitive and selective inhibitor of ATR, Gartisertib exhibits a high binding affinity with a Ki of less than 150 pM. It effectively inhibits ATR-mediated phosphorylation of checkpoint kinase 1 (Chk1) with an IC50 of 8 nM, demonstrating significant antitumor activity. This reagent is suitable for research applications in cancer biology, particularly in studies focusing on DNA damage response and checkpoint regulation.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1792214-00-6
Applications	Stable Isotope
Formula	C₂₅H₂₁D₈F₂N₉O₃
Molecular Weight	549.60
Synonyms	VX-803-d8; M4344-d8; ATR inhibitor 2-d8
SMILES	O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(N4CCC(C(N5C([2H])([2H])C([2H])([2H])N(C6COC6)C([2H])([2H])C5([2H])[2H])=O)CC4)C(F)=CN=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.