GGTI-286 hydrochloride is a selective inhibitor of geranylgeranyltransferase I (GGTase I) with a potency that is 25-fold greater than the methyl ester of FTI-276 (IC50 = 2 μM). This compound demonstrates a strong preference for inhibiting the geranylgeranylation of Rap1A over the farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 μM and >30 μM, respectively). Additionally, GGTI-286 hydrochloride effectively inhibits the stimulation of oncogenic K-Ras4B, with an IC50 of 1 μM, making it a valuable tool for research in cancer biology and signal transduction pathways.
GGTI-286 hydrochloride is a selective inhibitor of geranylgeranyltransferase I (GGTase I) with a potency that is 25-fold greater than the methyl ester of FTI-276 (IC50 = 2 μM). This compound demonstrates a strong preference for inhibiting the geranylgeranylation of Rap1A over the farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 μM and >30 μM, respectively). Additionally, GGTI-286 hydrochloride effectively inhibits the stimulation of oncogenic K-Ras4B, with an IC50 of 1 μM, making it a valuable tool for research in cancer biology and signal transduction pathways.
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