GI-149893 is a selective topoisomerase I (TopoI) inhibitor that disrupts the religation of DNA, leading to irreversible DNA damage in tumor cells. This compound demonstrates significant cytotoxic effects against various cancer cell lines, including colon carcinoma (HT-29/SW-48), breast cancer (MX-1), and prostate cancer xenografts (PC-3). GI-149893 serves as a valuable tool for cancer research, particularly in the exploration of therapeutic strategies targeting TopoI.
GI-149893 is a selective topoisomerase I (TopoI) inhibitor that disrupts the religation of DNA, leading to irreversible DNA damage in tumor cells. This compound demonstrates significant cytotoxic effects against various cancer cell lines, including colon carcinoma (HT-29/SW-48), breast cancer (MX-1), and prostate cancer xenografts (PC-3). GI-149893 serves as a valuable tool for cancer research, particularly in the exploration of therapeutic strategies targeting TopoI.
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