GI-530159 is a selective opener of TREK1 and TREK2 potassium channels, exhibiting an EC50 of 0.76 μM for TREK1. This compound demonstrates a significant ability to reduce excitability in rat dorsal root ganglion neurons, indicating potential analgesic effects. GI-530159 is valuable for research applications focused on pain modulation and the physiological roles of TREK channels in neuronal activity.
GI-530159 is a selective opener of TREK1 and TREK2 potassium channels, exhibiting an EC50 of 0.76 μM for TREK1. This compound demonstrates a significant ability to reduce excitability in rat dorsal root ganglion neurons, indicating potential analgesic effects. GI-530159 is valuable for research applications focused on pain modulation and the physiological roles of TREK channels in neuronal activity.
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