Fig. 1 · Structure
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Gilteritinib-d8
Stable Isotope
Gilteritinib-d8 is a deuterated form of Gilteritinib, a potent ATP-competitive inhibitor targeting FLT3 and AXL receptors, with IC50 values of 0.29 nM and 0.73 nM, respectively. This stable isotope is utilized in studies involving metabolic pathways, pharmacokinetics, and drug distribution in biological systems. Gilteritinib-d8 serves as an essential tool for researchers investigating FLT3/AXL-related signaling pathways and their implications in hematological malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2377109-74-3 |
| Applications | Stable Isotope |
| Formula | C29H36D8N8O3 |
| Molecular Weight | 560.76 |
| Synonyms | ASP2215-d8 |
| SMILES | NC(C(C(NC1=CC(OC)=C(N2CCC(N3C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C3([2H])[2H])C)CC2)C=C1)=N4)=NC(CC)=C4NC5CCOCC5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.