Gisadenafil is a selective, orally active phosphodiesterase 5 (PDE5) inhibitor with an IC50 of 3.6 nM. By inhibiting PDE5, it effectively prevents the degradation of cyclic guanosine monophosphate (cGMP), leading to increased intracellular cGMP levels. This mechanism has potential applications in the treatment of erectile dysfunction and pulmonary hypertension, facilitating improved vasodilation and blood flow.
Gisadenafil is a selective, orally active phosphodiesterase 5 (PDE5) inhibitor with an IC50 of 3.6 nM. By inhibiting PDE5, it effectively prevents the degradation of cyclic guanosine monophosphate (cGMP), leading to increased intracellular cGMP levels. This mechanism has potential applications in the treatment of erectile dysfunction and pulmonary hypertension, facilitating improved vasodilation and blood flow.
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