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Biological Activity
Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.
Targets
| SUR1 | SUR2A | SUR2B | ||
| 3 nM | 5.4 nM | 7.3 nM |
| In vitro | DMSO | 10 mg/mL (20.38 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.38 mL | 101.91 mL | 203.82 mL |
| 0.5 mM | 4.08 mL | 20.38 mL | 40.76 mL |
| 1 mM | 2.04 mL | 10.19 mL | 20.38 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
*The above data is based on the productmolecular weight 490.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10430 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 93479-97-1 |
| Formula | C24H34N4O5S |
| M. Wt | 490.62 |
| Purity | >98% |
| Synonyms | Amary |
| SMILES | CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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