GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) that effectively targets the estrogen receptor (ER) with an IC50 of 1.14 nM. It demonstrates significant binding affinity to the ER Y537S mutant (IC50 = 29.5 nM), making it a valuable tool for research applications in oncology. GLL398 has shown its ability to inhibit tumor growth in xenograft models of breast cancer, highlighting its potential for therapeutic strategies in ER-positive breast cancer.
GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) that effectively targets the estrogen receptor (ER) with an IC50 of 1.14 nM. It demonstrates significant binding affinity to the ER Y537S mutant (IC50 = 29.5 nM), making it a valuable tool for research applications in oncology. GLL398 has shown its ability to inhibit tumor growth in xenograft models of breast cancer, highlighting its potential for therapeutic strategies in ER-positive breast cancer.
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