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GLP-1R agonist 30

GLP-1R Agonist

GLP-1R agonist 30 is a highly selective and orally active agonist of the glucagon-like peptide-1 receptor (GLP-1R), demonstrating an EC50 of 0.048 nM. It displays significant selectivity with EC50 values greater than 20 μM for GLP-2 receptor, GIP receptor, and glucagon receptor. This compound enhances cAMP signaling while minimizing hERG inhibition, indicating favorable safety profiles. It effectively improves glucose tolerance and promotes insulin secretion in B-hGLP1R knock-in mouse models, making it a valuable tool for research applications in diabetes and metabolic disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	3108380-54-4
Applications	GLP-1R Agonist
Formula	C₃₃H₃₂F₃N₅O₄
Molecular Weight	619.63
SMILES	FC1=C(COC2=CC=CC(C3=CCN(CC3)CC4=NC5=C(N=C(C=C5)C(O)=O)N4C[C@H]6OCC6)=N2)C=CC(C7CC(F)(C7)F)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.