GluN2B-NMDAR Allosteric Modulator 1 is a selective positive allosteric modulator of the GluN2B subunit of the NMDA receptor. It enhances glutamate- and aspartate-induced GluN2B-NMDAR-mediated currents, exhibiting EC50 values of 43.7 nM and 18 nM, respectively. This compound demonstrates significant potential in reversing anxiety-like behaviors and cognitive impairments in murine models. It serves as a valuable tool for researching neurological disorders, particularly those related to anxiety.
GluN2B-NMDAR Allosteric Modulator 1 is a selective positive allosteric modulator of the GluN2B subunit of the NMDA receptor. It enhances glutamate- and aspartate-induced GluN2B-NMDAR-mediated currents, exhibiting EC50 values of 43.7 nM and 18 nM, respectively. This compound demonstrates significant potential in reversing anxiety-like behaviors and cognitive impairments in murine models. It serves as a valuable tool for researching neurological disorders, particularly those related to anxiety.
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