GNE-149 is a potent antagonist of estrogen receptor alpha (ERα) with an IC50 of 0.053 nM, demonstrating high selectivity as a selective estrogen receptor degrader (SERD). This compound exhibits significant biological activity in the modulation of ERα signaling pathways, making it a valuable tool in breast cancer research. Its ability to degrade ERα may provide insights into therapeutic strategies targeting estrogen-dependent tumors.
GNE-149 is a potent antagonist of estrogen receptor alpha (ERα) with an IC50 of 0.053 nM, demonstrating high selectivity as a selective estrogen receptor degrader (SERD). This compound exhibits significant biological activity in the modulation of ERα signaling pathways, making it a valuable tool in breast cancer research. Its ability to degrade ERα may provide insights into therapeutic strategies targeting estrogen-dependent tumors.
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