GNE-616

Catalog No.: A19046

Nav1.7 inhibitor

GNE-616

GNE-616 Chemical Structure

CAS NO. 2349371-81-7

GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (Ki of 0.79 nM and Kd of 0.38 nM for hNav1.7) for the treatment of chronic pain.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (Ki of 0.79 nM and Kd of 0.38 nM for hNav1.7) for the treatment of chronic pain.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.6 mL 93.02 mL 186.04 mL
0.5 mM 3.72 mL 18.6 mL 37.21 mL
1 mM 1.86 mL 9.3 mL 18.6 mL
5 mM 0.37 mL 1.86 mL 3.72 mL

*The above data is based on the productmolecular weight 537.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19046
Actions Inhibitor
M. Wt 537.53
Formula C24H23F4N5O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2349371-81-7
Synonyms GNE 616, GNE616
SMILES O=S(C1=C(F)C=C2[[email protected]@H](N3[[email protected]@H](C4=NC=CC=C4)C[[email protected]@H](C(F)(F)F)CC3)CCOC2=C1)(NC5=NC=NC=C5)=O

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