GNE 9605

Catalog No.: A14149

LRRK2 inhibitor

GNE 9605 Chemical Structure

CAS NO. 1536200-31-3

GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
25 mg
$400.00
10mM * 1mL in DMSO
$167.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GNE-9605 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki and IC50 of 2 nM and 19 nM, respectively.
Targets
LRRK2 LRRK2
2 nM(Ki)19 nM
In vitro DMSO 89 mg/mL (197.85 mM)
Water <1 mg/mL (<1 mM)
Ethanol 12 mg/mL heating (26.67 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.23 mL 111.15 mL 222.31 mL
0.5 mM 4.45 mL 22.23 mL 44.46 mL
1 mM 2.22 mL 11.12 mL 22.23 mL
5 mM 0.44 mL 2.22 mL 4.45 mL

*The above data is based on the productmolecular weight 449.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14149
Actions No
M. Wt 449.83
Formula C17H20ClF4N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1536200-31-3
Synonyms GNE-9605,GNE9605
SMILES CNC1=NC(=NC=C1C(F)(F)F)NC2=C(N(N=C2)[[email protected]]3CCN(C[[email protected]@H]3F)C4COC4)Cl

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