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Biological Activity
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.1 mL | 170.51 mL | 341.03 mL |
| 0.5 mM | 6.82 mL | 34.1 mL | 68.21 mL |
| 1 mM | 3.41 mL | 17.05 mL | 34.1 mL |
| 5 mM | 0.68 mL | 3.41 mL | 6.82 mL |
*The above data is based on the productmolecular weight 293.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13507 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 77603-42-0 |
| Formula | C15H7N3O4 |
| M. Wt | 293.23 |
| Purity | >98% |
| Synonyms | 8-Nitrotryptanthrin, GNF-PF3777 |
| SMILES | O=C1N2C(C(C3=C2C=CC([N+]([O-])=O)=C3)=O)=NC4=CC=CC=C41 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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