GPR6 inverse agonist 2 is a selective inverse agonist targeting the GPR6 receptor, exhibiting an IC50 of less than 0.1 μM. This compound shows notable selectivity over GPR3, with IC50 values ranging from 1 to 30 μM, and demonstrates preliminary cardiac safety with an IC50 of 21.71 μM for hERG. GPR6 inverse agonist 2 is suitable for research applications investigating movement disorders, including Parkinson's disease, offering valuable insights into therapeutic avenues for these conditions.
GPR6 inverse agonist 2 is a selective inverse agonist targeting the GPR6 receptor, exhibiting an IC50 of less than 0.1 μM. This compound shows notable selectivity over GPR3, with IC50 values ranging from 1 to 30 μM, and demonstrates preliminary cardiac safety with an IC50 of 21.71 μM for hERG. GPR6 inverse agonist 2 is suitable for research applications investigating movement disorders, including Parkinson's disease, offering valuable insights into therapeutic avenues for these conditions.
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