GpTx-1 is a peptide-derived antagonist of the NaV1.7 sodium channel, extracted from the venom of the Chilean spider Grammostola porteri. It exhibits potent inhibitory activity with an IC50 of 10 nM specifically for the NaV1.7 channel, demonstrating substantial selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), highlighting greater than 20-fold and over 950-fold selectivity, respectively. GpTx-1 is valuable in research applications focused on pain modulation and neurological disorders linked to NaV1.7 channel activity.
GpTx-1 is a peptide-derived antagonist of the NaV1.7 sodium channel, extracted from the venom of the Chilean spider Grammostola porteri. It exhibits potent inhibitory activity with an IC50 of 10 nM specifically for the NaV1.7 channel, demonstrating substantial selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), highlighting greater than 20-fold and over 950-fold selectivity, respectively. GpTx-1 is valuable in research applications focused on pain modulation and neurological disorders linked to NaV1.7 channel activity.
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