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Catalog No.: A13251

TLR7 agonist


GS-9620 Chemical Structure

CAS NO. 1228585-88-3

GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.

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  • Yu-Geun Ji, .et al. Determination of motolimod concentration in rat plasma by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study, J Pharm Biomed Anal, 2019, 12 November, 112987
  • Zhikuan Zhang, .et al. Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands, Cell Reports, 2018, 25(12): 3371-3381.e5 PMID: 30566863

Biological Activity

GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.
In vitro DMSO 1 mg/mL (2.43 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.36 mL 121.8 mL 243.6 mL
0.5 mM 4.87 mL 24.36 mL 48.72 mL
1 mM 2.44 mL 12.18 mL 24.36 mL
5 mM 0.49 mL 2.44 mL 4.87 mL

*The above data is based on the productmolecular weight 410.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13251
Actions Agonist
CAS No. 1228585-88-3
Formula C22H30N6O2
M. Wt 410.51
Purity >98%
Synonyms GS9620, GS 9620

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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