GSK 1210151A (I-BET151)

Catalog No.: A11783

BET Bromodomain Inhibitor

GSK 1210151A (I-BET151)

GSK 1210151A (I-BET151) Chemical Structure

CAS NO. 1300031-49-5

GSK1210151A is a novel selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4.

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  • Momeny M, .et al. Inhibition of bromodomain and extraterminal domain reduces growth and invasive characteristics of chemoresistant ovarian carcinoma cells, Anticancer Drugs, 2018, Nov;29(10):1011-1020 PMID: 30096128

Biological Activity

GSK1210151A is a novel selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4.
BRD3 (Cell-free assay) BRD2 (Cell-free assay) BRD4 (Cell-free assay)
0.25 μM0.5 μM0.79 μM
In vitro DMSO Insoluble
Water Insoluble
Ethanol 27 mg/mL (64.99 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.07 mL 120.37 mL 240.73 mL
0.5 mM 4.81 mL 24.07 mL 48.15 mL
1 mM 2.41 mL 12.04 mL 24.07 mL
5 mM 0.48 mL 2.41 mL 4.81 mL

*The above data is based on the productmolecular weight 415.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11783
Actions Inhibitor
CAS No. 1300031-49-5
Formula C23H21N5O3
M. Wt 415.4
Purity >98%
Synonyms GSK1210151A
SMILES CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)[[email protected]](C)C5=CC=CC=N5)OC

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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