GSK 5959

Catalog No.: A16092

BRPF1 bromodomain inhibitor

GSK 5959

GSK 5959 Chemical Structure

CAS NO. 901245-65-6

GSK 5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.

Availability: In stock

Package Price Qty
5 mg
$55.00
10 mg
$90.00
50 mg
$265.00
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Biological Activity

GSK 5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.
In vitro DMSO 5 mg/mL (12.68 mM)
Water Insoluble
Ethanol 3 mg/mL (7.6 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.35 mL 126.75 mL 253.5 mL
0.5 mM 5.07 mL 25.35 mL 50.7 mL
1 mM 2.53 mL 12.67 mL 25.35 mL
5 mM 0.51 mL 2.53 mL 5.07 mL

*The above data is based on the productmolecular weight 394.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16092
Actions Inhibitor
CAS No. 901245-65-6
Formula C22H26N4O3
M. Wt 394.48
Purity >98%
Synonyms GSK-5959, GSK5959
SMILES O=C(NC1=C(N2CCCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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