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GSK J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX
Targets
| JMJD3 (KDM6B) | UTX (KDM6A) | |||
| 28 nM | 53 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.68 mL | 128.39 mL | 256.77 mL |
| 0.5 mM | 5.14 mL | 25.68 mL | 51.35 mL |
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
*The above data is based on the productmolecular weight 389.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12918 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 389.45 |
| Formula | C22H23N5O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1373422-53-7 |
| Synonyms | 0 |
| SMILES | C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O |
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