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$0.00 - Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
Biological Activity
GSK J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX
Targets
| JMJD3 (KDM6B) | UTX (KDM6A) | |||
| 28 nM | 53 nM |
| In vitro | DMSO | 70 mg/mL (179.74 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.68 mL | 128.39 mL | 256.77 mL |
| 0.5 mM | 5.14 mL | 25.68 mL | 51.35 mL |
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
*The above data is based on the productmolecular weight 389.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12918 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1373422-53-7 |
| Formula | C22H23N5O2 |
| M. Wt | 389.45 |
| Purity | >98% |
| Synonyms | 0 |
| SMILES | C1CN(CCC2=CC=CC=C21)C3=CC(=NC(=N3)C4=CC=CC=N4)NCCC(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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